1 00:00:06,309 --> 00:00:04,570 and welcome to Mission Control Houston 2 00:00:07,749 --> 00:00:06,319 we're going to send the signal out to 3 00:00:09,369 --> 00:00:07,759 Marshall Space Flight Center in 4 00:00:11,499 --> 00:00:09,379 Huntsville Alabama the payload 5 00:00:13,629 --> 00:00:11,509 operations integration Center so the 6 00:00:15,129 --> 00:00:13,639 Lori Meggs is standing by there to tell 7 00:00:17,980 --> 00:00:15,139 us more about the research on the space 8 00:00:19,269 --> 00:00:17,990 station hi Lori hi Kelly we're learning 9 00:00:21,279 --> 00:00:19,279 about the human body and how it 10 00:00:23,980 --> 00:00:21,289 functions in microgravity is paramount 11 00:00:26,080 --> 00:00:23,990 to future spaceflight astronauts are 12 00:00:28,120 --> 00:00:26,090 asked to participate in studies for the 13 00:00:30,099 --> 00:00:28,130 human research program and one of those 14 00:00:32,290 --> 00:00:30,109 studies going on right now is called the 15 00:00:34,119 --> 00:00:32,300 functional task tests and I recently 16 00:00:35,860 --> 00:00:34,129 spoke with the principal investigator of 17 00:00:38,500 --> 00:00:35,870 that to find out a little bit more about 18 00:00:40,810 --> 00:00:38,510 what they're doing we're involved in an 19 00:00:43,090 --> 00:00:40,820 ISS study called a functional task test 20 00:00:46,390 --> 00:00:43,100 and the functional task test is really 21 00:00:49,180 --> 00:00:46,400 looking at how multiple physiological 22 00:00:51,460 --> 00:00:49,190 systems impact ability of astronauts do 23 00:00:53,200 --> 00:00:51,470 functional tasks over the years we've 24 00:00:55,859 --> 00:00:53,210 done a really good job with defining how 25 00:00:58,570 --> 00:00:55,869 individual physiological systems in a 26 00:01:00,429 --> 00:00:58,580 change as a result of spaceflight but 27 00:01:03,399 --> 00:01:00,439 we've never put the pieces together in 28 00:01:05,350 --> 00:01:03,409 one complete study but more importantly 29 00:01:06,970 --> 00:01:05,360 we've never linked those physiological 30 00:01:09,420 --> 00:01:06,980 changes to functional changes in 31 00:01:11,980 --> 00:01:09,430 astronauts really operational changes so 32 00:01:14,680 --> 00:01:11,990 functional test test is really an 33 00:01:17,140 --> 00:01:14,690 integrative study involving three of the 34 00:01:19,450 --> 00:01:17,150 labs at JSC the cardiovascular lab 35 00:01:22,990 --> 00:01:19,460 neuroscience lab exercise physiology lab 36 00:01:25,720 --> 00:01:23,000 are focused specifically on making that 37 00:01:29,320 --> 00:01:25,730 link between functional changes and the 38 00:01:31,000 --> 00:01:29,330 underlying physiology involved and you 39 00:01:32,710 --> 00:01:31,010 ultimately the reason for doing that is 40 00:01:34,990 --> 00:01:32,720 we're interested in developing 41 00:01:37,090 --> 00:01:35,000 countermeasures and we want to focus on 42 00:01:38,800 --> 00:01:37,100 the counter measures on countermeasures 43 00:01:41,290 --> 00:01:38,810 on systems that really make a difference 44 00:01:44,080 --> 00:01:41,300 in terms of functional change have you 45 00:01:46,540 --> 00:01:44,090 seen over the years a lot of functional 46 00:01:48,399 --> 00:01:46,550 change and things that change in in my 47 00:01:50,440 --> 00:01:48,409 sure I mean so that some of the more 48 00:01:52,899 --> 00:01:50,450 obvious changes we see are in partial 49 00:01:54,760 --> 00:01:52,909 stability and ability to walk we've done 50 00:01:57,100 --> 00:01:54,770 previous studies where crew members 51 00:01:58,870 --> 00:01:57,110 walked obstacle courses and did those 52 00:02:01,060 --> 00:01:58,880 type of functions as we see significant 53 00:02:03,580 --> 00:02:01,070 partial instability half after 54 00:02:05,530 --> 00:02:03,590 spaceflight that's my sort of area of 55 00:02:07,300 --> 00:02:05,540 interest but of course you see changes 56 00:02:09,219 --> 00:02:07,310 in well and other physiological systems 57 00:02:11,680 --> 00:02:09,229 to let the cardiovascular system there's 58 00:02:13,180 --> 00:02:11,690 orthostatic intolerance which is the 59 00:02:14,840 --> 00:02:13,190 potential for fainting when when when 60 00:02:16,490 --> 00:02:14,850 the crewmember stands up 61 00:02:18,020 --> 00:02:16,500 as muscle performance changes their 62 00:02:20,420 --> 00:02:18,030 strength changes there's muscle atrophy 63 00:02:22,250 --> 00:02:20,430 so all those systems sort of combined 64 00:02:24,200 --> 00:02:22,260 together to create the change in 65 00:02:26,690 --> 00:02:24,210 functional outcome so how are we 66 00:02:29,270 --> 00:02:26,700 studying this how is it operationally 67 00:02:32,390 --> 00:02:29,280 for you this is a pre and post flight 68 00:02:34,670 --> 00:02:32,400 study and we test them three times 69 00:02:37,130 --> 00:02:34,680 pre-flight and then we were able to test 70 00:02:40,490 --> 00:02:37,140 them on 24 hours after landing the crew 71 00:02:42,230 --> 00:02:40,500 comes from ISS lands in Russia they fly 72 00:02:43,550 --> 00:02:42,240 back to Johnson Space Center and we 73 00:02:45,620 --> 00:02:43,560 start doing the data collection they are 74 00:02:48,470 --> 00:02:45,630 about 24 hours after landing and then we 75 00:02:50,690 --> 00:02:48,480 test them six days and 30 days done the 76 00:02:53,210 --> 00:02:50,700 way we test them is we have a set of 77 00:02:55,010 --> 00:02:53,220 functional tests that we do which are 78 00:02:59,660 --> 00:02:55,020 things like obstacle course testing 79 00:03:02,390 --> 00:02:59,670 hatch opening letter climbing various 80 00:03:04,880 --> 00:03:02,400 task of object displacement so various 81 00:03:06,550 --> 00:03:04,890 hands-on functional tasks and then we 82 00:03:10,430 --> 00:03:06,560 have a set of corresponding 83 00:03:12,650 --> 00:03:10,440 physiological tasks that look at various 84 00:03:15,550 --> 00:03:12,660 physiological changes that include 85 00:03:17,990 --> 00:03:15,560 changes in muscle performance 86 00:03:19,640 --> 00:03:18,000 neurological changes and cardiovascular 87 00:03:20,930 --> 00:03:19,650 changes and putting all those pieces 88 00:03:22,970 --> 00:03:20,940 together is really what we're trying to 89 00:03:24,350 --> 00:03:22,980 do I'm going to tell you I'd hate to be 90 00:03:25,760 --> 00:03:24,360 on Space Station then come back and have 91 00:03:29,210 --> 00:03:25,770 to run an obstacle course that would not 92 00:03:31,070 --> 00:03:29,220 be yes it is challenging absolutely tell 93 00:03:34,310 --> 00:03:31,080 me how long this has been going on and 94 00:03:36,620 --> 00:03:34,320 how long it will go on well we've 95 00:03:39,140 --> 00:03:36,630 already completed seven subjects we're 96 00:03:42,260 --> 00:03:39,150 asking for 13 subjects so we're about 97 00:03:44,270 --> 00:03:42,270 halfway through our subject count even 98 00:03:46,190 --> 00:03:44,280 doing the experiment for about two two 99 00:03:48,800 --> 00:03:46,200 and a half years we expect another two 100 00:03:51,050 --> 00:03:48,810 years to collect the rest of our data we 101 00:03:53,060 --> 00:03:51,060 learn anything so far that you can share 102 00:03:54,890 --> 00:03:53,070 some of the preliminary data when we 103 00:03:56,510 --> 00:03:54,900 look at some of the functional tasks so 104 00:03:59,900 --> 00:03:56,520 the clearly the functional tasks that 105 00:04:01,790 --> 00:03:59,910 require partial stability are are 106 00:04:04,670 --> 00:04:01,800 affected the mouse or the obstacle 107 00:04:06,950 --> 00:04:04,680 course test our posture stability test 108 00:04:08,720 --> 00:04:06,960 those are the tests tests that have less 109 00:04:10,220 --> 00:04:08,730 requirement for posterous to be like 110 00:04:12,650 --> 00:04:10,230 hatch opening where you can hold on to 111 00:04:16,000 --> 00:04:12,660 the hatch those testing that are less 112 00:04:18,250 --> 00:04:16,010 impaired by by by spaceflight 113 00:04:19,840 --> 00:04:18,260 and along the lines of human research we 114 00:04:20,980 --> 00:04:19,850 want to share some news about a recently 115 00:04:23,020 --> 00:04:20,990 identified health problem with 116 00:04:25,630 --> 00:04:23,030 astronauts vision and some new research 117 00:04:27,310 --> 00:04:25,640 that that is leading to is called the 118 00:04:29,500 --> 00:04:27,320 visual impairment and intracranial 119 00:04:31,930 --> 00:04:29,510 pressure risk and it has become the 120 00:04:33,490 --> 00:04:31,940 number one human space flight risk when 121 00:04:35,440 --> 00:04:33,500 we talk about intracranial pressure 122 00:04:37,300 --> 00:04:35,450 we're talking about pressure inside the 123 00:04:38,920 --> 00:04:37,310 brain and on-orbit crew members 124 00:04:41,380 --> 00:04:38,930 experience fluid shifts to the head 125 00:04:43,510 --> 00:04:41,390 caused by microgravity and therefore 126 00:04:45,520 --> 00:04:43,520 it's hypothesized that all crew members 127 00:04:47,740 --> 00:04:45,530 have elevated intracranial pressure to 128 00:04:49,510 --> 00:04:47,750 some degree researchers have linked this 129 00:04:52,000 --> 00:04:49,520 increased pressure to changes in vision 130 00:04:53,800 --> 00:04:52,010 and long-duration astronauts and when 131 00:04:56,410 --> 00:04:53,810 the vision impairment study began all 132 00:04:58,300 --> 00:04:56,420 crew members pre-flight had normal eye 133 00:05:00,220 --> 00:04:58,310 examinations but post flight 134 00:05:02,040 --> 00:05:00,230 measurements showed a degradation and 135 00:05:04,990 --> 00:05:02,050 vision primarily increasing 136 00:05:06,790 --> 00:05:05,000 farsightedness 41 crew members have 137 00:05:08,710 --> 00:05:06,800 flown to date and of those 19 were 138 00:05:11,050 --> 00:05:08,720 identified as having visual changes on 139 00:05:13,360 --> 00:05:11,060 their return six did not have symptoms 140 00:05:15,850 --> 00:05:13,370 and 16 others could not be classified 141 00:05:17,080 --> 00:05:15,860 classified as they flew in the early 142 00:05:18,640 --> 00:05:17,090 increments which did not have the 143 00:05:22,000 --> 00:05:18,650 imaging techniques available as in the 144 00:05:23,410 --> 00:05:22,010 last six to seven years now researchers 145 00:05:25,620 --> 00:05:23,420 are looking at finding a technique to 146 00:05:27,880 --> 00:05:25,630 measure these visual changes in flight 147 00:05:30,250 --> 00:05:27,890 non-invasively and to understand what's 148 00:05:31,960 --> 00:05:30,260 contributing to it a technique like this 149 00:05:33,640 --> 00:05:31,970 is highly sought after on earth as well 150 00:05:35,500 --> 00:05:33,650 as to measure intracranial pressure and 151 00:05:37,660 --> 00:05:35,510 NASA is on the cutting edge of that 152 00:05:39,940 --> 00:05:37,670 research and identifying devices that 153 00:05:41,530 --> 00:05:39,950 could be used in flight results of these 154 00:05:43,480 --> 00:05:41,540 studies may also be relevant for 155 00:05:45,820 --> 00:05:43,490 patients suffering from I diseases here 156 00:05:47,440 --> 00:05:45,830 on earth such as glaucoma NASA's human 157 00:05:49,330 --> 00:05:47,450 research program will look at this risk 158 00:05:50,800 --> 00:05:49,340 over the next 10 years and find 159 00:05:52,660 --> 00:05:50,810 investigators to study the intracranial